Anthony J Lee Selected Research

tucatinib

1/2022	Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl.
1/2022	Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases.
1/2021	Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.

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Anthony J Lee Research Topics

Disease

4	Breast Neoplasms (Breast Cancer) 01/2022 - 06/2008
3	Neoplasms (Cancer) 01/2022 - 06/2008
3	Peripheral Nervous System Diseases (PNS Diseases) 04/2015 - 04/2011
2	Hepatitis C 01/2016 - 01/2016
1	Neoplasm Micrometastasis 01/2022
1	Brain Neoplasms (Brain Tumor) 01/2022
1	Hematologic Neoplasms (Hematological Malignancy) 01/2017
1	Carcinogenesis 06/2008
1	Pituitary Neoplasms (Pituitary Adenoma) 06/2008

Drug/Important Bio-Agent (IBA)

3	tucatinibIBA 01/2022 - 01/2021
2	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2021
2	Protease Inhibitors (Protease Inhibitor)IBA 01/2016 - 04/2011
1	Lapatinib (GW572016)FDA Link 01/2022
1	neratinibIBA 01/2022
1	human ERBB2 proteinIBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	venetoclaxIBA 01/2017
1	paritaprevirIBA 01/2016
1	dasabuvirIBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 10/2012
1	estradiol-17-stearateIBA 06/2008
1	estradiol 17-palmitateIBA 06/2008
1	AcidsIBA 06/2008
1	EstersIBA 06/2008
1	Estradiol (Delestrogen)FDA LinkGeneric 06/2008
1	Fatty Acids (Saturated Fatty Acids)IBA 06/2008

Therapy/Procedure

2	Highly Active Antiretroviral Therapy (HAART) 04/2015 - 04/2011